The impacts of the COVID-19 pandemic have gone far beyond the disease itself. In addition to the increasing number of COVID-19 deaths, the pandemic has deepened social and economic inequalities. These indirect impacts have been compounded by pervasive gender inequalities, with profound consequences, especially for women, girls, and people of diverse gender identities. There has been an escalation in gender-based violence within households, increasing risk of child marriages and female genital mutilation, and an increased burden of unpaid care work, with impacts on mental health. Communities of people affected by HIV are, again, at the crossroads of injustice and targeted discrimination. Measures to control the pandemic have reduced access to essential health and social welfare services, including sexual and reproductive health services, reduced employment and labour force participation, and decimated many household incomes. Here again, women have borne the brunt of marginalisation, particularly those working in the informal sector. Intersectionality analyses have highlighted the inextricable effects of poverty, racial discrimination, harmful gender norms, and limited agency and opportunities for women, especially already marginalised women, even when they represent most of the front-line health workers. The diversion of funds from other health and development programmes into economic recovery means that the pandemic is further eroding health gains made over decades, stalling progress on tackling gender inequalities.